RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

RANKL is a type II membrane protein bearing close homology to TNFSF members TRAIL, FasL, and TNF-a. has been definite for its key characteristic role in bone metabolism the immune system. It an apoptosis regulator gene, binding partner of osteoprotegerin OPG, ligand receptor RANK, it controls cell proliferation by modifying levels. Osteoblasts stromal stem cells activator NFκ-B (RANKL), binds apparent on surface osteoclasts their predecessors. Osteoprotegerin (OPG) secreted osteoblasts osteogenic keep skeleton from extreme resorption averting interacting with RANK osteocytes. The critical cause alveolar remodelling during orthodontic tooth movement. RANKL/OPG proportion marrow thus significant element mass normal disease conditions. This article reviews RANKL/RANK/OPG system other tissues Orthodontic